The main story has Dreyfuss, Estevez, and O'Donnell going undercover as a family. Their attempt to find a missing witness, crucial to a Mafia trial, leads to humorous situations.

When a state's witness, Lu Delano (Cathy Moriarty) who was under protective custody because she was going to testify against the mob in Las Vegas, runs away to Washington when her safe house is blown up by the mob's hit man, Tony Castellano (Miguel Ferrer). Officer Chris Lecce (Dreyfuss), his partner, Bill Reimers (Estevez) and Gina Garrett (O'Donnell) & her large dog set up a stakeout in the large home next to the home of the woman's friends, Pam & Brian O'Hara, (Dennis Farina & Marcia Srassman), who live in a ritzy area of Puget Sound, Washington, along the waterfront.

Against their better judgment, Chris and Bill are forced to take novice O'Donnell, and her large Rottweiler,along, because she is a higher up with clout, being the Assistant District Attorney. Funny complications ensue when a baseball, O'Donnell, her dog, and Dreyfuss's personal life problems with Maria cause complications, and interminglings between the watched and the watchers. An exciting ending, which includes a shoot out between good guys and bad guys is most exciting and suspenseful. Personal problems are also solved, of course.

This is the rare sequel that's as good as, and in some ways better, than the original. The addition of O'Donnell is a plus, as is the unlikely concept of Estevez passing himself off as Dreyfuss and O'Donnell's grown son.

"Another Stakeout" benefits from great locations. The Washington State locations are both beautiful and fresh, not having been filmed a jillion times before by Hollywood.

Dreyfuss and Estevez have great comic timing together. Like the best of the great comic teams, Estevez and Dreyfuss have a mutual affection that's infectious.